A little of both actually - I got this case from tone007, and he and I did some measurements before I bought it, just to make sure it would actually fit.
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Anything smaller than standard ATX probably won't work without heavy modifications. Also make sure there are plenty of slots on back so that you have places to mount connectors and such.
It turned out that the drive's case normally serves as a heat sink in stock units, same as in the RAMLink.